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We then performed metagenomic Examination on a similar samples to find the existence of reads from pks+ genes. As shown in Fig. three, the pks+ genes may be detected while in the sequencing info from the samples (both cancers or typical) in 19 people outside of 30, Hence validating the existence from the mutational and indel signatures (see also Supplementary Figs. 6 and seven). Notably, whereas the presence of pks+ genes from the sample signifies the existence from the genotoxic E. coli strands, the mutational signature is the results of generally earlier exposure, as a result it could be amassed in cell genomes prior to now with out pks+ currently being current in the mean time of sampling.

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